IUBMB Enzyme Nomenclature


Accepted name: glucose-6-phosphatase

Reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate

Other name(s): glucose 6-phosphate phosphatase

Systematic name: D-glucose-6-phosphate phosphohydrolase

Comments: Wide distribution in animal tissues. Also catalyses potent transphosphorylations from carbamoyl phosphate, hexose phosphates, diphosphate, phosphoenolpyruvate and nucleoside di- and triphosphates, to D-glucose, D-mannose, 3-methyl-D-glucose or 2-deoxy-D-glucose [cf. EC (phosphoramidate—hexose phosphotransferase), EC (diphosphate—glycerol phosphotransferase) and EC (phosphoamidase)].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9001-39-2


1. Anchors, J.M. and Karnovsky, N.L. Purification of cerebral glucose-6-phosphatase. An enzyme involved in sleep. J. Biol. Chem. 250 (1975) 6408-6416. [PMID: 169241]

2. Colilla, W., Jorgenson, R.A. and Nordlie, R.C. Mammalian carbamyl phosphate : glucose phosphotransferase and glucose-6-phosphate phosphohydrolase: extended tissue distribution. Biochim. Biophys. Acta 377 (1975) 117. [PMID: 164220]

3. Nordlie, R.C. Glucose-6-phosphatase, hydrolytic and synthetic activities. In: Boyer, P.D. (Ed.), The Enzymes, 3rd edn., vol. 4, Academic Press, New York, 1971, pp. 543-610.

4. Nordlie, R.C. Metabolic regulation by multifunctional glucose-6-phosphatase. Curr. Top. Cell. Regul. 8 (1974) 33. [PMID: 4370737]

[EC created 1961]

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