IUBMB Enzyme Nomenclature


Accepted name: 7-methylguanosine nucleotidase

Reaction: (1) N7-methyl-GMP + H2O = N7-methyl-guanosine + phosphate
(2) CMP + H2O = cytidine + phosphate

Other name(s): cytosolic nucleotidase III-like; cNIII-like; N7-methylguanylate 5'-phosphatase

Systematic name: N7-methyl-GMP phosphohydrolase

Comments: The enzyme also has low activity with N7-methyl-GDP, producing N7-methyl-GMP. Does not accept AMP or GMP, and has low activity with UMP.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Buschmann, J., Moritz, B., Jeske, M., Lilie, H., Schierhorn, A. and Wahle, E. Identification of Drosophila and human 7-methyl GMP-specific nucleotidases. J. Biol. Chem. 288 (2013) 2441-2451. [PMID: 23223233]

[EC created 2013]

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