IUBMB Enzyme Nomenclature


Accepted name: phosphatidylinositol-3,5-bisphosphate 3-phosphatase

Reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate

Glossary: 1-phosphatidyl-1D-myo-inositol 5-phosphate = PtdIns5P
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate = PtdIns(3,5)P2

Other name(s): MTMR; PtdIns-3,5-P2 3-Ptase

Systematic name: 1-phosphatidyl-1D-myo-inositol-3,5-bisphosphate 3-phosphohydrolase

Comments: The enzyme is found in both plants and animals. It also has the activity of EC (phosphatidylinositol-3-phosphatase).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Walker, D.M., Urbe, S., Dove, S.K., Tenza, D., Raposo, G. and Clague, M.J. Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity. Curr. Biol. 11 (2001) 1600-1605. [PMID: 11676921]

2. Berger, P., Bonneick, S., Willi, S., Wymann, M. and Suter, U. Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1. Hum. Mol. Genet. 11 (2002) 1569-1579. [PMID: 12045210]

3. Ding, Y., Lapko, H., Ndamukong, I., Xia, Y., Al-Abdallat, A., Lalithambika, S., Sadder, M., Saleh, A., Fromm, M., Riethoven, J.J., Lu, G. and Avramova, Z. The Arabidopsis chromatin modifier ATX1, the myotubularin-like AtMTM and the response to drought. Plant Signal Behav 4 (2009) 1049-1058. [PMID: 19901554]

[EC created 2014]

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