Reaction: Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides
Other name(s): 5'-exonuclease; 5'-phosphodiesterase; 5'-nucleotide phosphodiesterase
Systematic name: oligonucleotide 5'-nucleotidohydrolase
Comments: Low activity towards polynucleotides. A 3'-phosphate terminus on the substrate inhibits hydrolysis.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9025-82-5
1. Khorana, G.H. Phosphodiesterases. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd edn., vol. 5, Academic Press, New York, 1961, pp. 79-94.