IUBMB Enzyme Nomenclature


Accepted name: phosphodiesterase I

Reaction: Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides

Other name(s): 5'-exonuclease; 5'-phosphodiesterase; 5'-nucleotide phosphodiesterase

Systematic name: oligonucleotide 5'-nucleotidohydrolase

Comments: Low activity towards polynucleotides. A 3'-phosphate terminus on the substrate inhibits hydrolysis.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9025-82-5


1. Khorana, G.H. Phosphodiesterases. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd edn., vol. 5, Academic Press, New York, 1961, pp. 79-94.

[EC created 1961]

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