IUBMB Enzyme Nomenclature


Accepted name: 3',5'-cyclic-nucleotide phosphodiesterase

Reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate

Other name(s): cyclic 3',5'-mononucleotide phosphodiesterase; PDE; cyclic 3',5'-nucleotide phosphodiesterase; cyclic 3',5'-phosphodiesterase; 3',5'-nucleotide phosphodiesterase; 3':5'-cyclic nucleotide 5'-nucleotidohydrolase; 3',5'-cyclonucleotide phosphodiesterase; cyclic nucleotide phosphodiesterase; 3', 5'-cyclic nucleoside monophosphate phosphodiesterase; 3': 5'-monophosphate phosphodiesterase (cyclic CMP); cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP); cyclic 3',5-nucleotide monophosphate phosphodiesterase; nucleoside 3',5'-cyclic phosphate diesterase; nucleoside-3',5-monophosphate phosphodiesterase

Systematic name: 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase

Comments: Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9040-59-9


1. Fischer, U. and Amrhein, N. Cyclic nucleotide phosphodiesterase of Chlamydomonas reinhardtii. Biochim. Biophys. Acta 341 (1974) 412-420. [PMID: 4365506]

2. Nair, K.G. Purification and properties of 3',5'-cyclic nucleotide phosphodiesterase from dog heart. Biochemistry 5 (1966) 150-157. [PMID: 4287216]

[EC created 1972, modified 1976]

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