IUBMB Enzyme Nomenclature

EC 3.1.7.8

Accepted name: tuberculosinol synthase

Reaction: tuberculosinyl diphosphate + H2O = tuberculosinol + diphosphate

For diagram of reaction click here.

Glossary: tuberculosinyl diphosphate = halima-5,13-dien-15-yl diphosphate

Other name(s): Rv3378c

Systematic name: tuberculosinyl diphosphate diphosphohydrolase (tuberculosinol forming)

Comments: Only found in species of Mycobacterium that cause tuberculosis. In addition, it also gives isotuberculosinol in 1:1 mixture, cf EC 3.1.7.9, isotuberculosinol synthase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Nakano, C., Ootsuka, T., Takayama, K., Mitsui, T., Sato, T. and Hoshino, T. Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R,S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome. Biosci. Biotechnol. Biochem. 75 (2011) 75-81. [PMID: 21228491]

2. Hoshino, T., Nakano, C., Ootsuka, T., Shinohara, Y. and Hara, T. Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis. Org. Biomol. Chem. 9 (2011) 2156-2165. [PMID: 21290071]

[EC 3.1.7.8 created 2011]


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