IUBMB Enzyme Nomenclature

EC 3.1.8.2

Accepted name: diisopropyl-fluorophosphatase

Reaction: diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride

Other name(s): DFPase; tabunase; somanase; organophosphorus acid anhydrolase; organophosphate acid anhydrase; OPA anhydrase; diisopropylphosphofluoridase; dialkylfluorophosphatase; diisopropyl phosphorofluoridate hydrolase; isopropylphosphorofluoridase; diisopropylfluorophosphonate dehalogenase

Systematic name: diisopropyl-fluorophosphate fluorohydrolase

Comments: Acts on phosphorus anhydride bonds (such as phosphorus-halide and phosphorus-cyanide) in organophosphorus compounds (including 'nerve gases'). Inhibited by chelating agents; requires divalent cations. Related to EC 3.1.8.1 aryldialkylphosphatase. Previously listed as EC 3.8.2.1.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9032-18-2

References:

1. Augustinsson, K.-B. and Heimburger, G. Enzymatic hydrolysis of organophosphorus compounds. I. Occurrence of enzymes hydrolysing dimethyl-amido-ethoxy-phosphoryl cyanide (Tabun). Acta Chem. Scand. 8 (1954) 753-761.

2. Augustinsson, K.-B. and Heimburger, G. Enzymatic hydrolysis of organophosphorus compounds. II. Analysis of reaction products in experiments with Tabun and some properties of blood plasma tabunase. Acta Chem. Scand. 8 (1954) 762-767.

3. Augustinsson, K.-B. and Heimburger, G. Enzymatic hydrolysis of organophosphorus compounds. IV. Specificity studies. Acta Chem. Scand. 8 (1954) 1533-1541.

4. Cohen, J.A. and Warringa, M.G.P.J. Purification and properties of dialkylfluorophosphatase. Biochim. Biophys. Acta 26 (1957) 29-39.

5. Mounter, L.A. Enzymic hydrolysis of organophosphorus compounds. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd edn., vol. 4, Academic Press, New York, 1960, pp. 541-550.

6. Reiner, E., Aldridge, W.N. and Hoskin, C.G. (Eds.) Enzymes Hydrolysing Organophosphorus Compounds, Ellis Horwood Ltd., Chichester, UK, 1989.

[EC 3.1.8.2 created 1961 as EC 3.8.2.1, transferred 1992 to EC 3.1.8.2]


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