IUBMB Enzyme Nomenclature

EC 3.2.1.123

Accepted name: endoglycosylceramidase

Reaction: oligoglycosylglucosyl-(1↔1)-ceramide + H2O = ceramide + oligoglycosylglucose

Other name(s): endoglycoceramidase; EGCase; glycosyl-N-acetyl-sphingosine 1,1-β-D-glucanohydrolase, oligoglycosylglucosylceramide glycohydrolase; oligoglycosylglucosyl(1↔1)ceramide glycohydrolase

Systematic name: oligoglycosylglucosyl-(1↔1)-ceramide glycohydrolase

Comments: An enzyme from Rhodococcus sp. that degrades various acidic and neutral glycosphingolipids to oligosaccharides and ceramides, by cleaving a glucosyl bond. Does not act on monoglycosylceramides. cf. EC 3.2.1.62 glycosylceramidase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 105503-61-5

References:

1. Ito, M. and Yamagata, T. A novel glycosphingolipid-degrading enzyme cleaves the linkage between the oligosaccharide and ceramide of neutral and acidic glycosphingolipids. J. Biol. Chem. 261 (1986) 14278-14282. [PMID: 3771534]

[EC 3.2.1.123 created 1989]


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