IUBMB Enzyme Nomenclature

EC 3.2.1.130

Accepted name: glycoprotein endo-α-1,2-mannosidase

Reaction: Hydrolysis of the terminal α-D-glucosyl-(1,3)-D-mannosyl unit from the GlcMan9(GlcNAc)2 oligosaccharide component of the glycoprotein produced in the Golgi membrane

Other name(s): glucosylmannosidase; endo-α-D-mannosidase; endo-α-mannosidase; endomannosidase; glucosyl mannosidase

Systematic name: glycoprotein glucosylmannohydrolase

Comments: Involved in the synthesis of glycoproteins.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 108022-16-8

References:

1. Lubas, W.A. and Spiro, R.G. Golgi endo-α-D-mannosidase from rat liver, a novel N-linked carbohydrate unit processing enzyme. J. Biol. Chem. 262 (1987) 3775-3781. [PMID: 3818665]

2. Tulsiani, D.R.P., Coleman, V.P. and Touster, O. Asparagine-linked glycoprotein biosynthesis in rat brain: identification of glucosidase I, glucosidase II, and endomannosidase (glucosyl mannosidase). Arch. Biochem. Biophys. 277 (1990) 114-121. [PMID: 2407194]

[EC 3.2.1.130 created 1990]


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