IUBMB Enzyme Nomenclature


Accepted name: poly(ADP-ribose) glycohydrolase

Reaction: hydrolyses poly(ADP-ribose) at glycosidic (1"-2') linkage of ribose-ribose bond to produce free ADP-D-ribose

For diagram click here.

Comments: Specific to (1"-2') linkage of ribose-ribose bond of poly(ADP-D-ribose).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9068-16-0


1. Miwa, M. and Sugimura, T. Splitting of the ribose-ribose linkage of poly(adenosine diphosphate-ribose) by a calf thymus extract. J. Biol. Chem. 246 (1971) 6362-6364. [PMID: 4331388]

2. Lin, W., Ame, J.C., Aboul-Ela, N., Jacobson, E.L. and Jacobson, M.K. Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase. J. Biol. Chem. 272 (1997) 11895-11901. [PMID: 9115250]

[EC created 2000]

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