IUBMB Enzyme Nomenclature


Accepted name: glucosylceramidase

Reaction: a D-glucosyl-N-acylsphingosine + H2O = D-glucose + an N-acylsphingosine

For diagram of the reaction click here.

Other name(s): psychosine hydrolase; glucosphingosine glucosylhydrolase; GlcCer-β-glucosidase; β-D-glucocerebrosidase; glucosylcerebrosidase; β-glucosylceramidase; ceramide glucosidase; glucocerebrosidase; glucosylsphingosine β-glucosidase; glucosylsphingosine β-D-glucosidase

Systematic name: D-glucosyl-N-acylsphingosine glucohydrolase

Comments: Also acts on glucosylsphingosine (cf. EC glycosylceramidase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37228-64-1


1. Brady, R.O., Kanfer, J.N. and Shapiro, D. The metabolism of glucocerebrosides. I. Preparation and properties of a glucocerebroside-cleaving enzyme from spleen tissue. J. Biol. Chem. 240 (1966) 39-43.

2. Vaccaro, A.M., Muscillo, M. and Suzuki, K. Characterization of human glucosylsphingosine glucosyl hydrolase and comparison with glucosylceramidase. Eur. J. Biochem. 146 (1985) 315-321. [PMID: 3967661]

[EC created 1972]

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