Reaction: Hydrolysis of alkylated DNA, releasing 3-methyladenine
Other name(s): deoxyribonucleate 3-methyladenine glycosidase I; 3-methyladenine DNA glycosylase I; DNA-3-methyladenine glycosidase I
Systematic name: alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
Comments: Involved in the removal of alkylated bases from DNA in Escherichia coli (cf. EC 220.127.116.11 methylated-DNA[protein]-cysteine S-methyltransferase).
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 89287-37-6
1. Evensen, G. and Seeberg, E. Adaptation to alkylation resistance involves the induction of a DNA glycosylase. Nature 296 (1982) 773-775. [PMID: 7040984]
2. Karran, P., Hjelmgren, T. and Lindahl, T. Induction of a DNA glycosylase for N-methylated purines is part of the adaptive response to alkylating agents. Nature 296 (1982) 770-773. [PMID: 7040983]
3. Thomas, L., Yang, C.-H. and Goldthwait, D.A. Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenine. Biochemistry 21 (1982) 1162-1169. [PMID: 7041972]