Reaction: NAD+ + H2O = ADP-ribose + nicotinamide
Other name(s): NADase; DPNase; DPN hydrolase; NAD hydrolase; diphosphopyridine nucleosidase; nicotinamide adenine dinucleotide nucleosidase; NAD glycohydrolase; NAD nucleosidase; nicotinamide adenine dinucleotide glycohydrolase
Systematic name: NAD+ glycohydrolase
Comments: This enzyme can also hydrolyse NADP+ to yield phospho-ADP-ribose and nicotinamide, but more slowly.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9032-65-9
References:
1. Hofmann, E.C.G. and Rapoport, S. DPN- und TPN-spezifische Nukleosidasen in Erythrozyten. Biochim. Biophys. Acta 18 (1955) 296 only.
2. Nakazawa, K., Ueda, K., Honjo, T., Yoshihara, K., Nishizuka, Y. and Hayaishi, O. Nicotinamide adenine dinucleotide glycohydrolases and poly adenosine diphosphate ribose synthesis in rat liver. Biochem. Biophys. Res. Commun. 32 (1968) 143-149. [PMID: 5672131]
3. Ueda, K., Fukushima, M., Okayamo, H. and Hayaishi, O. Nicotinamide adenine dinucleotide glycohydrolase from rat liver nuclei. Isolation and characterization of a new enzyme. J. Biol. Chem. 250 (1975) 7541-7546. [PMID: 240831]
4. Yamamoto-Katayama, S., Ariyoshi, M., Ishihara, K., Hirano, T., Jingami, H. and Morikawa, K. Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities. J. Mol. Biol. 316 (2002) 711-723. [PMID: 11866528]