Reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide
Other name(s): nicotinamide adenine dinucleotide (phosphate) nucleosidase; triphosphopyridine nucleotidase; NAD(P) nucleosidase; NAD(P)ase; nicotinamide adenine dinucleotide (phosphate) glycohydrolase
Systematic name: NAD(P)+ glycohydrolase
Comments: Also catalyses transfer of ADP-ribose(P) residues.
Links to other databases: BRENDA, EXPASY, GTD, KEGG, CAS registry number: 9025-46-1
References:
1. Alivasatos, S.G.A. and Woolley, D.W. Solubilization and purification of the diphosphopyridine nucleotidase from beef spleen. J. Biol. Chem. 219 (1956) 823-832.
2. Zatman, L.J., Kaplan, N.O. and Colowick, S.P. Inhibition of spleen diphosphopyridine nucleotidase by nicotinamide, an exchange reaction. J. Biol. Chem. 200 (1953) 197-212.
3. Zatman, L.J., Kaplan, N.O., Colowick, S.P. and Ciotti, M.M. Formation of the isonicotinic acid hydrazide analog of DPN. J. Am. Chem. Soc. 75 (1953) 3293-3294.