IUBMB Enzyme Nomenclature


Accepted name: adenosylhomocysteine nucleosidase

Reaction: S-adenosyl-L-homocysteine + H2O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

For diagram click here or here.

Other name(s): S-adenosylhomocysteine hydrolase (ambiguous); S-adenosylhomocysteine nucleosidase; 5'-methyladenosine nucleosidase; S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase; AdoHcy/MTA nucleosidase

Systematic name: S-adenosyl-L-homocysteine homocysteinylribohydrolase

Comments: Also acts on S-methyl-5'-thioadenosine to give adenine and S-methyl-5-thioribose (cf. EC, methylthioadenosine nucleosidase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9055-10-1


1. Duerre, J.A. A hydrolytic nucleosidase acting on S-adenosylhomocysteine and on 5-methylthioadenosine. J. Biol. Chem. 237 (1962) 3737-3741.

2. Ferro, A.J., Barrett, A. and Shapiro, S.K. Kinetic properties and the effect of substrate analogues on 5'-methylthioadenosine nucleosidase from Escherichia coli. Biochim. Biophys. Acta 438 (1976) 487-494. [PMID: 782530]

[EC created 1972, modified 2004]

Return to EC 3.2.2 home page
Return to EC 3.2 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page