IUBMB Enzyme Nomenclature

EC 3.4.11.21

Accepted name: aspartyl aminopeptidase

Reaction: Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate

Comments: Aminoacyl-arylamides are poor substrates. This is an abundant cytosolic enzyme in mammalian cells, in peptidase family M18 of aminopeptidase I

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 9074-83-3

References

1. Kelly, J.A., Neidle, E.L. and Neidle, A. An aminopeptidase from mouse brain cytosol that cleaves N-terminal acidic amino acid residues. J. Neurochem. 40 (1983) 1727-1734. [PMID: 6854330]

2. Wilk, S., Wilk, E. and Magnusson, R.P. Purification, characterization and cloning of a cytosolic aspartyl aminopeptidase. J. Biol. Chem. 273 (1998) 15961-15970. [PMID: 9632644]

[EC 3.4.11.21 created 2000]


Return to EC 3.4.11 home page
Return to EC 3.4 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page