IUBMB Enzyme Nomenclature


Accepted name: chymotrypsin C

Reaction: Preferential cleavage: Leu, Tyr, Phe, Met, Trp, Gln, Asn

Comments: Formed from pig chymotrypsinogen C, and from cattle subunit II of procarboxypeptidase A. Reacts more readily with Tos-Leu-CH2Cl than Tos-Phe-CH2Cl in contrast to chymotrypsin. In peptidase family S1 (trypsin family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 9036-09-3


1. Peanasky, R.J., Gratecos, D., Baratti, J. and Rovery, M. Mode of activation and N-terminal sequence of subunit II in bovine procarboxypeptidase A and of porcine chymotrypsinogen C. Biochim. Biophys. Acta 181 (1969) 82-92. [PMID: 5792601]

2. Folk, J.E. Chymotrypsin C (porcine pancreas). Methods Enzymol. 19 (1970) 109-112

3. Wilcox, P.E. Chymotrypsinogens - chymotrypsins. Methods Enzymol. 19 (1970) 64-108

[EC created 1972]

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