IUBMB Enzyme Nomenclature

EC 3.4.21.39

Accepted name: chymase

Reaction: Preferential cleavage: Phe > Tyr > Trp > Leu

Other names: mast cell protease I; skeletal muscle protease; skin chymotryptic proteinase; mast cell serine proteinase, chymase; skeletal muscle (SK) protease

Comments: In mast cell granules. In peptidase family S1 (trypsin family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 97501-92-3

References

1. Woodbury, R.G., Everitt, M. and Neurath, H. Mast cell proteases. Methods Enzymol. 80 (1981) 588-609. [PMID: 7043202]

2. Powers, J.C., Tanaka, T., Harper, J.W., Minematsu, Y., Barker, L., Lincoln, D., Crumley, K.V., Fraki, J.E., Schechter, N.M., Lazarus, G.G., Nakajima, K., Nakashino, K., Neurath, H. and Woodbury, R.G. Mammalian chymotrypsin-like enzymes. Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors. Biochemistry 24 (1985) 2048-2058. [PMID: 3893542]

3. Johnson, L.A., Moon, K.E. and Eisenberg, M. Purification to homogeneity of the human skin chymotryptic proteinase "chymase". Anal. Biochem. 155 (1986) 358-364. [PMID: 2425663]

[EC 3.4.21.39 created 1981]


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