IUBMB Enzyme Nomenclature


Accepted name: complement factor D

Reaction: Selective cleavage of ArgLys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor

Other names: C3 proactivator convertase; properdin factor D esterase; factor D; factor D (complement)

Comments: A component of the alternative pathway of complement activation. This reaction is analogous to the activation of complement component C2 by complement subcomponent C. In peptidase family S1 (trypsin family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 37213-56-2


1. Reid, K.B.M., Johnson, D.M.A., Gagnon, J. and Prohaska, R. Preparation of human factor of the alternative pathway of complement. Methods Enzymol. 80 (1981) 134-143. [PMID: 6918766]

2. Müller-Eberhard, H.J. Molecular organization and function of the complement system. Annu. Rev. Biochem. 57 (1988) 321-347. [PMID: 3052276]

[EC created 1981]

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