IUBMB Enzyme Nomenclature


Accepted name: thrombin

Reaction: Selective cleavage of ArgGly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B

Other names: fibrinogenase; thrombase; thrombofort; topical; thrombin-C; tropostasin; activated blood-coagulation factor II; blood-coagulation factor IIa; factor IIa; E thrombin; β-thrombin; γ-thrombin

Comments: Formed from prothrombin. More selective than trypsin and plasmin. In peptidase family S1 (trypsin family). Formerly EC

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 9002-04-4


1. Baughman, D.J. Thrombin assay. Methods Enzymol. 19 (1970) 145-157

2. Magnusson, S. Bovine prothrombin and thrombin. Methods Enzymol. 19 (1970) 157-184

3. Miller, K.D. Horse prothrombin. Methods Enzymol. 19 (1970) 140-145

4. Lundblad, R.L., Kingdon, H.S. and Mann, K.G. Thrombin. Methods Enzymol. 45 (1976) 156-176. [PMID: 1011989]

5. Mann, K.G. Prothrombin. Methods Enzymol. 45 (1976) 123-156. [PMID: 1011988]

6. Davie, E.W., Fujikawa, K., Kurachi, K. and Kisiel, W. The role of serine proteases in the blood coagulation cascade. Adv. Enzymol. 48 (1979) 277-318. [PMID: 367103]

7. Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C. Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates. Biochemistry 23 (1984) 644-650. [PMID: 6370301]

8. MacGillivray, R.T.A. and Davie, E.W. Characterization of bovine prothrombin mRNA and its translation product. Biochemistry 23 (1984) 1626-1634. [PMID: 6326805]

[EC created 1961 as EC, transferred 1972 to EC]

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