IUBMB Enzyme Nomenclature


Accepted name: endopeptidase La

Reaction: Hydrolysis of proteins in presence of ATP

Other names: ATP-dependent serine proteinase; lon proteinase; protease La; proteinase La; ATP-dependent lon proteinase; ATP-dependent protease La; Escherichia coli proteinase La; Escherichia coli serine proteinase La; gene lon protease; gene lon proteins; PIM1 protease; PIM1 proteinase; serine protease La

Comments: Product of the lon gene in Escherichia coli. ATP hydrolysis is linked with peptide bond hydrolysis; vanadate inhibits both reactions. Type example of peptidase family S16. A similar enzyme occurs in animal mitochondria

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 79818-35-2


1. Desautels, M. and Goldberg, A.L. Demonstration of an ATP-dependent, vanadate-sensitive endoprotease in the matrix of rat liver mitochondria. J. Biol. Chem. 257 (1982) 11673-11679. [PMID: 6749845]

2. Larimore, F.S., Waxman, L. and Goldberg, A.L. Studies of the ATP-dependent proteolytic enzyme, protease La, from Escherichia coli. J. Biol. Chem. 257 (1982) 4187-4195. [PMID: 7040380]

3. Chin, D.T., Goff, S.A., Webster, T., Smith, T. and Goldberg, A.L. Sequence of the lon gene in Escherichia coli. A heat-shock gene which encodes the ATP-dependent protease La. J. Biol. Chem. 263 (1988) 11718-11728. [PMID: 3042779]

[EC created 1986]

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