IUBMB Enzyme Nomenclature


Accepted name: protein C (activated)

Reaction: Degradation of blood coagulation factors Va and VIIIa

Other name(s): blood-coagulation factor XIVa; activated blood coagulation factor XIV; activated protein C; autoprothrombin II-A; protein Ca; APC; GSAPC

Comments: A peptidase of family S1 (trypsin family), one of the γ-carboxyglutamic acid-containing coagulation factors. Formed from protein C, the proenzyme that circulates in plasma, by the action of a complex of thrombin with thrombomodulin, or by serine endopeptidases present in several snake venoms

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 42617-41-4


1. Esmon, C.T. The regulation of natural anticoagulant pathways. Science 235 (1987) 1348-1352. [PMID: 3029867]

2. Esmon, C.T. The roles of protein C and thrombomodulin in the regulation of blood coagulation. J. Biol. Chem. 264 (1989) 4743-4746. [PMID: 2538457]

[EC created 1992]

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