IUBMB Enzyme Nomenclature


Accepted name: pancreatic elastase II

Reaction: Preferential cleavage: Leu, Met and Phe. Hydrolyses elastin

Other names: pancreatic elastase 2

Comments: A peptidase of family S1 (trypsin family) formed by activation of proelastase II from mammalian pancreas by trypsin. Usually, only one of the pancreatic elastases (see also EC is expressed in a given species; human pancreatic elastase is of type II

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 75603-19-9


1. Fletcher, T.S., Shen, W.-F. and Largman, C. Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA. Biochemistry 26 (1987) 7256-7261. [PMID: 3427074]

2. Shirasu, Y., Yoshida, H., Matsuki, S., Takemura, K., Ikeda, N., Shimada, Y., Ozawa, T., Mikayama, T., Iijima, H., Ishida, A., Sato, Y., Tamai, Y., Tanaka, J. and Ikenaga, H. Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2. J. Biochem. (Tokyo) 102 (1987) 1555-1563. [PMID: 2834346]

[EC created 1992]

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