IUBMB Enzyme Nomenclature

EC 3.4.21.80

Accepted name: streptogrisin A

Reaction: Hydrolysis of proteins with specificity similar to chymotrypsin

Other names: Streptomyces griseus protease A; protease A; proteinase A; Streptomyces griseus proteinase A; Streptomyces griseus serine proteinase 3; Streptomyces griseus serine proteinase A

Comments: From Streptomyces griseus. A component of Pronase, in family S1 (trypsin family). Not inhibited by Tos-Phe-CH2Cl or ovomucoid

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 55326-50-6

References

1. Johnson, P. and Smillie, L.B. The disulfide bridge sequences of a serine protease of wide specificity from Streptomyces griseus. Can. J. Biochem. 49 (1971) 548-562. [PMID: 5575653]

2. Sielecki, A.R., Hendrickson, W.A., Broughton, C.G., Delbaere, L.T.J., Brayer, G.D. and James, M.N.G. Protein structure refinement: Streptomyces griseus serine protease A at 1.8 Å resolution. J. Mol. Biol. 134 (1979) 781-804. [PMID: 119870]

3. James, M.N.G., Sielecki, A.R., Brayer, G.D., Delbaere, L.T.J. and Bauer, C.-A. Structures of product and inhibitor complexes of Streptomyces griseus protease A at 1.8 Å resolution. J. Mol. Biol. 144 (1980) 43-88. [PMID: 6783761]

4. Delbaere, L.T.J. and Brayer, G.D. The 1.8 Å structure of the complex between chymostatin and Streptomyces griseus protease A. A model for serine protease catalytic tetrahedral intermediates. J. Mol. Biol. 183 (1985) 89-103. [PMID: 3892018]

5. Henderson, G., Krygsman, P., Liu, C.J., Davey, C.C. and Malek, L.T. Characterization and structure of genes for proteases A and B from Streptomyces griseus. J. Bacteriol. 169 (1987) 3778-3784. [PMID: 3112129]

[EC 3.4.21.80 created 1993]


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