IUBMB Enzyme Nomenclature

EC 3.4.22.34

Accepted name: legumain

Reaction: Hydrolysis of proteins and small molecule substrates at -AsnXaa- bonds

Other names: asparaginyl endopeptidase; citvac; proteinase B (ambiguous); hemoglobinase (ambiguous); PRSC1 gene product (Homo sapiens); vicilin peptidohydrolase; bean endopeptidase; vicilin peptidohydrolase

Comments: Best known from legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes. Not inhibited by compound E-64. Type example of peptidase family C13

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 149371-18-6

References:

1. Hara-Nishimura, I. Asparaginyl endopeptidase. In: Handbook of Proteolytic Enzymes (Barrett, A.J., Rawlings, N.D. and Woessner, J.F. eds), pp. 746-749 (1998) Academic Press, London

2. Dalton, J.P. and Brindley, P.J. Schistosome legumain. In: Handbook of Proteolytic Enzymes (Barrett, A.J., Rawlings, N.D. and Woessner, J.F. eds), pp. 749-754 (1998) Academic Press, London

3. Chen, J.-M., Rawlings, N.D., Stevens, R.A.E. and Barrett, A.J. Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases. FEBS Letters 441 (1998) 361-365. [PMID: 9891971]

[EC 3.4.22.34 created 1992, modified 2000]


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