IUBMB Enzyme Nomenclature


Accepted name: calpain-1

Reaction: Broad endopeptidase specificity

Other name(s): μ-calpain; calcium-activated neutral protease I

Comments: In peptidase family C2. Requires Ca2+ at micromolar concentrations for activity. Cytosolic in animal cells. The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC, calpain-2.

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 78990-62-2


1. Dutt, P., Spriggs, C.N., Davies, P.L., Jia, Z. and Elce, J.S. Origins of the difference in Ca2+ requirement for activation of μ- and m-calpain. Biochem. J. 367 (2002) 263-269. [PMID: 12014988]

[EC created 1981 as EC, transferred 2003 to EC]

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