IUBMB Enzyme Nomenclature

EC 3.4.22.70

Accepted name: sortase A

Reaction: The enzyme catalyzes a cell wall sorting reaction in which a surface protein with a sorting signal containing a LPXTG motif is cleaved between the Thr and Gly residue. The resulting threonine carboxyl end of the protein is covalently attached to a pentaglycine cross-bridge of peptidoglycan

Other name(s): SrtA; SrtA protein; SrtA sortase

Comments: In peptidase family C60.

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, MEROPS, Metacyc, CAS registry number:

References:

1. Ton-That, H., Liu, G., Mazmanian, S.K., Faull, K.F. and Schneewind, O. Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif. Proc. Natl. Acad. Sci. USA 96 (1999) 12424-12429. [PMID: 10535938]

2. Zong, Y., Bice, T.W., Ton-That, H., Schneewind, O. and Narayana, S.V. Crystal structures of Staphylococcus aureus sortase A and its substrate complex. J. Biol. Chem. 279 (2004) 31383-31389. [PMID: 15117963]

3. Race, P.R., Bentley, M.L., Melvin, J.A., Crow, A., Hughes, R.K., Smith, W.D., Sessions, R.B., Kehoe, M.A., McCafferty, D.G. and Banfield, M.J. Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism. J. Biol. Chem. 284 (2009) 6924-6933. [PMID: 19129180]

[EC 3.4.22.70 created 2009]


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