IUBMB Enzyme Nomenclature


Accepted name: renin

Reaction: Cleavage of Leu bond in angiotensinogen to generate angiotensin I

Other names: angiotensin-forming enzyme; angiotensinogenase

Comments: Formed from prorenin in plasma and kidney. In peptidase family A1 (pepsin A family). Formerly EC

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 9015-94-5


1. Inagami, T. and Murakami, K. Pure renin. Isolation from hog kidney and characterization. J. Biol. Chem. 252 (1977) 2978-2983. [PMID: 16012]

2. Slater, E.E. Renin. Methods Enzymol. 80 (1981) 427-442. [PMID: 7043197]

3. Inagami, T. Structure and function of renin. J. Hypertension 7 (Suppl. 2) (1989) S3-S8. [PMID: 2785652]

4. Sielecki, A.R., Hayakawa, K., Fujinaga, M., Murphy, M.E.P., Fraser, M., Muir, A.K., Carilli, C.T., Lewicki, J.A., Baxter, J.D. and James, M.N.G. Structure of recombinant human renin, a target for cardiovascular-active drugs, at 2.5 Å resolution. Science 243 (1989) 1346-1351. [PMID: 2493678]

[EC created 1961 as EC, transferred 1972 to EC, transferred 1981 to EC]

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