IUBMB Enzyme Nomenclature


Accepted name: barrierpepsin

Reaction: Selective cleavage of -Leu6Lys- bond in the pheromone α-mating factor

Other names: barrier proteinase; Bar proteinase

Comments: A secreted endopeptidase known from baker's yeast (Saccharomyces cerevisiae). In peptidase family A1 (pepsin A family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 152060-38-3


1. Mackay, V.L., Welch, S.K., Insley, M.Y., Manney, T.R., Holly, J., Saari, G.C. and Parker, M.L. The Saccharomyces cerevisiae BAR1 gene encodes an exported protein with homology to pepsin. Proc. Natl. Acad. Sci. USA 85 (1988) 55-59. [PMID: 3124102]

2. Mackay, V.L., Armstrong, J., Yip, C., Welch, S., Walker, K., Osborn, S., Sheppard, P. and Forstrom, J. Characterization of the bar proteinase, an extracellular enzyme from the yeast Saccharomyces cerevisiae. Adv. Exp. Med. Biol. 306 (1991) 161-172. [PMID: 1812704]

[EC created 1993]

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