Reaction: Similar in specificity to pepsin A preferring bulky hydrophobic amino acids in P1 and P1'
Comments: From the thermophilic archaeaon Sulfolobus acidocaldarius. Maximally active at pH 2 and 90 °C. Weakly inhibited by pepstatin but shows no sequence similarity to pepsin. Type example of peptidase family A5. Formerly EC 188.8.131.52
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 126125-05-1
1. Lin, X. and Tang, J. Thermopsin. Methods Enzymol. 248 (1995) 156-168. [PMID: 7674919]