IUBMB Enzyme Nomenclature


Accepted name: thermopsin

Reaction: Similar in specificity to pepsin A preferring bulky hydrophobic amino acids in P1 and P1'

Comments: From the thermophilic archaeaon Sulfolobus acidocaldarius. Maximally active at pH 2 and 90 °C. Weakly inhibited by pepstatin but shows no sequence similarity to pepsin. Type example of peptidase family A5. Formerly EC

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 126125-05-1


1. Lin, X. and Tang, J. Thermopsin. Methods Enzymol. 248 (1995) 156-168. [PMID: 7674919]

[EC created 1992 as EC, transferred 2000 to EC]

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