IUBMB Enzyme Nomenclature


Accepted name: plasminogen activator Pla

Reaction: Converts human Glu-plasminogen to plasmin by cleaving the Arg560Val peptide bond that is also hydrolysed by the mammalian u-plasminogen activator and t-plasminogen activator. Also cleaves arginyl bonds in other proteins

Comments: In peptidase family A26. From the bacterium Yersinia pestis that causes plague.

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, PDB, CAS registry number: 101028-08-4


1. Kukkonen, M., Lähteenmäki, K., Suomalainen, M., Kalkkinen, N., Emödy, L., Lång, H. and Korhonen, T.K. Protein regions important for plasminogen activation and inactivation of α2-antiplasmin in the surface protease Pla of Yersinia pestis. Mol. Microbiol. 40 (2001) 1097-1111. [PMID: 11401715]

[EC created 2003]

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