IUBMB Enzyme Nomenclature


Accepted name: IgA-specific metalloendopeptidase

Reaction: Cleavage of ProThr bond in the hinge region of the heavy chain of human IgA

Other names: immunoglobulin A1 proteinase; IgA protease; IgA1-specific proteinase; IgA1 protease; IgA1 proteinase

Comments: A 190 kDa enzyme found in several pathogenic species of Streptococcus such as sanguis and pneumoniae. Type example of peptidase family M26. There is also an IgA-specific prolyl endopeptidase of the serine-type (see EC, IgA-specific serine endopeptidase).

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 72231-73-3


1. Kornfeld, S.J. and Plaut, A.G. Secretory immunity and the bacterial IgA proteases. Rev. Infect. Dis. 3 (1981) 521-534. [PMID: 6792682]

2. Gilbert, J.V., Plaut, A.G. and Wright, A. Analysis of the immunoglobulin A protease gene of Streptococcus sanguis. Infect. Immun. 59 (1991) 7-17. [PMID: 1987065]

3. Gilbert, J.V., Plaut, A.G., Fishman, Y. and Wright, A. Cloning of the gene encoding streptococcal immunoglobulin A protease and its expression in Escherichia coli. Infect. Immun. 56 (1988) 1961-1966. [PMID: 3294181]

[EC created 1984]

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