IUBMB Enzyme Nomenclature


Accepted name: procollagen N-endopeptidase

Reaction: Cleaves the N-propeptide of collagen chain α1(I) at ProGln and of α1(II) and α2(I) at AlaGln

Other name(s): procollagen N-terminal peptidase; procollagen aminopeptidase; aminoprocollagen peptidase; aminoterminal procollagen peptidase; procollagen aminoterminal protease; procollagen N-terminal proteinase; type I/II procollagen N-proteinase; type III procollagen

Comments: Removes the propeptides of type I and II collagens prior to fibril assembly. Does not act on type III collagen. In peptidase family M12 (astacin family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 68651-94-5


1. Kohn, L.D., Iserky, C., Zupnik, J., Lenaers, A., Lee, G. and Lapiére, C.M. Calf tendon procollagen peptidase: its purification and endopeptidase mode of action. Proc. Natl. Acad. Sci. USA 71 (1974) 40-44. [PMID: 4204204]

2. Hojima, Y., McKenzie, J., van der Rest, M. and Prockop, D.J. Type I procollagen N-proteinase from chick embryo tendons. Purification of a new 500-kDa form of the enzyme and identification of the catalytically active polypeptides. J. Biol. Chem. 264 (1989) 11336-11345. [PMID: 2500439]

[EC created 1984]

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