IUBMB Enzyme Nomenclature


Accepted name: procollagen C-endopeptidase

Reaction: Cleavage of the C-terminal propeptide at AlaAsp in type I and II procollagens and at ArgAsp in type III

Other name(s): procollagen C-terminal proteinase; carboxyprocollagen peptidase; procollagen C-terminal peptidase; procollagen C-proteinase; procollagen C-terminal proteinase; procollagen carboxypeptidase; procollagen carboxy-terminal proteinase; procollagen peptidase

Comments: A 100 kDa endopeptidase the activity of which is increased by Ca2+ and by an enhancer glycoprotein. In peptidase family M12 (astacin family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 68651-95-6


1. Hojima, Y., van der Rest, M. and Prockop, D.J. Type I procollagen carboxyl-terminal proteinase from chick embryo tendons. Purification and characterization. J. Biol. Chem. 260 (1985) 15996-16003. [PMID: 3905801]

2. Kessler, E. and Adar, R. Type I procollagen C-proteinase from mouse fibroblasts. Purification and demonstration of a 55-kDa enhancer glycoprotein. Eur. J. Biochem. 186 (1989) 115-121. [PMID: 2689170]

[EC created 1992]

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