IUBMB Enzyme Nomenclature


Accepted name: aureolysin

Reaction: Cleavage of insulin B chain with specificity similar to that of thermolysin, preferring hydrophobic P1' residue. Activates the glutamyl endopeptidase (EC of Staphylococcus aureus

Other names: Staphylococcus aureus neutral proteinase; Staphylococcus aureus neutral protease

Comments: A metalloenzyme from Staphylococcus aureus earlier confused with staphylokinase (a non-enzymatic activator of plasminogen). Formerly EC and included in EC

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 39335-13-2


1. Arvidson, S. Studies on extracellular proteolytic enzymes from Staphylococcus aureus. II. Isolation and characterization of an EDTA-sensitive protease. Biochim. Biophys. Acta 302 (1973) 149-157. [PMID: 4632563]

2. Saheb, S.A. Purification et caractérisation d'une protéase extracellulaire de Staphylococcus aureus inhibée par l'E.D.T.A. Biochimie 58 (1976) 793-804. [PMID: 823980]

3. Drapeau, G.R. Role of a metalloprotease in activation of the precursor of staphylococcal protease. J. Bacteriol. 136 (1978) 607-613. [PMID: 711676]

4. Potempa, J., Porwit-Bohr, Z. and Travis, J. Stabilization vs. degradation of Staphylococcus aureus metalloproteinase Biochim. Biophys. Acta 993 (1989) 301-304. [PMID: 2512988]

[EC created 1972 as EC, part transferred 1992 to EC]

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