IUBMB Enzyme Nomenclature

EC 3.4.24.35

Accepted name: gelatinase B

Reaction: Cleavage of gelatin types I and V and collagen types IV and V

Other names: 92-kDa gelatinase; matrix metalloproteinase 9; type V collagenase; 92-kDa type IV collagenase; macrophage gelatinase; 95 kDa type IV collagenase/gelatinase; collagenase IV; collagenase type IV; gelatinase MMP 9; MMP 9; matrix metalloproteinase 9; type IV collagen metalloproteinase

Comments: Similar to gelatinase A, but possesses a further domain . In peptidase family M10 (interstitial collagenase family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 146480-36-6

References:

1. Hibbs, M.S., Hoidal, J.R. and Kang, A.H. Expression of a metalloproteinase that degrades native type V collagen and denatured collagens by cultured human alveolar macrophages. J. Clin. Invest. 80 (1987) 1644-1650. [PMID: 3680518]

2. Wilhelm, S.M., Collier, I.E., Marmer, B.L., Eisen, A.Z., Grant, G.A. and Goldberg, G.I. SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages. J. Biol. Chem. 264 (1989) 17213-17221. [PMID: 2551898]

3. Mainardi, C. L. and Hasty, K. A. Secretion and glycosylation of rabbit macrophage type V collagenase. Matrix 10 (1990) 84-90. [PMID: 2165210]

[EC 3.4.24.35 created 1992]


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