IUBMB Enzyme Nomenclature


Accepted name: ruberlysin

Reaction: Cleavage of His10Leu, Ala14Leu, Tyr16Leu and Gly23Phe bonds in the B chain of insulin; HisPro, ProPhe, and TrpSer of angiotensin I; and GlyPhe of Met enkephalin

Other names: Crotalus ruber metalloendopeptidase II; hemorrhagic toxin II

Comments: A 25 kDa hemorrhagic endopeptidase from the venom of the red rattlesnake (Crotalus ruber ruber) that cleaves fibrinogen. In peptidase family M12 (astacin family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, MEROPS, CAS registry number: 846020-01-7


1. Mori, N., Nikai, T., Sugihara, H. and Tu, A.T. Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom. Arch. Biochem. Biophys. 253 (1987) 108-121. [PMID: 2949699]

2. Takeya, H., Onikura, A., Nikai, T., Sugihara, H. and Iwanaga, S. Primary structure of a hemorrhagic metalloproteinase, HT- 2, isolated from the venom of Crotalus ruber ruber. J. Biochem. (Tokyo) 108 (1990) 711-719. [PMID: 2081731]

[EC created 1992]

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