IUBMB Enzyme Nomenclature

EC 3.4.24.67

Accepted name: choriolysin H

Reaction: Hydrolysis of the inner layer of fish egg envelope. Also hydrolysis of casein and small molecule substrates such as succinyl-Leu-Leu-Val-Tyr7-(4-methyl)coumarylamide

Other names: teleost hatching enzyme (component); high choriolytic enzyme (HCE)

Comments: Known from the teleost fish Oryzias latipes (medaka). Efficient dissolution of the egg membrane requires concerted action with choriolysin L. A 25.5 kDa peptidase in family M12 (astacin family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 177529-16-7

References

1. Yamagami, K. Isolation of a choriolytic enzyme (hatching enzyme) of the teleost, Oryzias latipes. Dev. Biol. 29 (1972) 343-348

2. Yasumasu, S., Iuchi, I. and Yamagami, K. Purification and partial characterization of high choriolytic enzyme (HCE), a component of the hatching enzyme of the teleost, Oryzias latipes. J. Biochem. (Tokyo) 105 (1989) 204-211. [PMID: 2656664]

3. Yasumasu, S., Katow, S., Umino, Y., Iuchi, I. and Yamagami, K. A unique proteolytic action of HCE, a constituent protease of a fish hatching enzyme: tight binding to its natural substrate, egg envelope. Biochem. Biophys. Res. Commun. 162 (1989) 58-63. [PMID: 2751672]

4. Yasumasu, S., Yamada, K., Akasaka, K., Mitsunaga, K., Iuchi, I., Shimada, H. and Yamagami, K. Isolation of cDNAs for LCE and HCE, two constituent proteases of the hatching enzyme of Oryzias latipes, and concurrent expression of their mRNAs during development. Dev. Biol. 153 (1992) 250-258. [PMID: 1397682]

5. Lee, K.S., Yasumasu, S., Nomura, K. and Iuchi, I. HCE, a constituent of the hatching enzymes of Oryzias latipes embryos, releases unique proline-rich polypeptides from its natural substrate, the hardened chorion. FEBS Lett. 339 (1993) 281-284. [PMID: 8112467]

[EC 3.4.24.67 created 1995]


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