IUBMB Enzyme Nomenclature


Accepted name: lysostaphin

Reaction: Hydrolysis of the -GlyGly- bond in the pentaglycine inter-peptide link joining staphylococcal cell wall peptidoglycans

Other names: glycyl-glycine endopeptidase

Comments: A zinc-dependent, 25-kDa endopeptidase from Staphylococcus simulans. Lyses cells of S. aureus, in particular, by its action on the cross-bridges of the cell wall. Type example of peptidase family M23

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 9011-93-2


1. Recsei, P.A., Gruss, A.D. and Novick, R.P. Cloning, sequence, and expression of the lysostaphin gene from Staphylococcus simulans. Proc. Natl. Acad. Sci. U.S.A. 84 (1987) 1127-1131

2. Baba, T. and Schneewind, O. Target cell specificity of a bacteriocin molecule: A C-terminal signal directs lysostaphin to the cell wall of Staphylococcus aureus. EMBO J. 15 (1996) 4789-4797

3. Thumm, G. and Götz, F. Studies on prolysostaphin processing and characterization of the lysostaphin immunity factor (Lif) of Staphylococcus simulans biovar staphylolyticus. Mol. Microbiol. 23 (1997) 1251-1265. [PMID: 9106216]

[EC created 1997]

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