Reaction: Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn37Leu. Other bonds hydrolysed include Gly35Ile in the propeptide of collagenase 3, and Asn341Phe, Asp441Leu and Gln354Thr in the aggrecan interglobular domain
Other name(s): matrix metalloproteinase 14
Comments: In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 161384-17-4
1. Itoh, Y., Takamura, A., Ito, N., Maru, Y., Sato, H., Suenaga, N., Aoki, T. and Seiki, M. Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion. EMBO J. 20 (2001) 4782-4793. [PMID: 11532942]
[EC 18.104.22.168 created 2003]