IUBMB Enzyme Nomenclature


Accepted name: ADAM 17 endopeptidase

Reaction: Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-AlaVal-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumour necrosis factor α (TNFα). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains

Other names: tumor necrosis factor α-converting enzyme; TACE

Comments: In peptidase family M12. In vivo, the cleavage of tumor necrosis factor α precursor releases the soluble, 17-kDa TNFα, which induces inflammation.

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 151769-16-3


1. Black, R.A. Tumor necrosis factor-α converting enzyme. Int. J. Biochem. Cell Biol. 34 (2002) 1-5. [PMID: 11733179]

[EC created 2003]

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