IUBMB Enzyme Nomenclature


Accepted name: asparaginase

Reaction: L-asparagine + H2O = L-aspartate + NH3

Other name(s): asparaginase II; L-asparaginase; colaspase; elspar; leunase; crasnitin; α-asparaginase

Systematic name: L-asparagine amidohydrolase

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9015-68-3


1. Halpern, Y.S. and Grossowicz, N. Hydrolysis of amides by extracts from mycobacteria. Biochem. J. 65 (1957) 716-720.

2. Ho, P.P.K., Frank, B.H. and Burck, P.J. Crystalline L-asparaginase from Escherichia coli B. Science 165 (1969) 510-512.

3. Suld, H.M. and Herbut, P.A. Guinea pig serum and liver L-asparaginases. Comparison of serum and papain-digested liver L-asparaginases. J. Biol. Chem. 245 (1970) 2797-2801. [PMID: 4987975]

[EC created 1961]

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