IUBMB Enzyme Nomenclature


Accepted name: choloylglycine hydrolase

Reaction: glycocholate + H2O = cholate + glycine

Glossary: glycocholate = N-(3α,7α,12α-trihydroxy-5β-cholan-24-oyl)glycine
cholate = 3α,7α,12α-trihydroxy-5β-cholan-24-oate

For diagram click here.

Other name(s): glycocholase; bile salt hydrolase; choloyltaurine hydrolase; 3α,7α,12α-trihydroxy-5β-cholan-24-oylglycine amidohydrolase

Systematic name: glycocholate amidohydrolase

Comments: Also acts on the 3α,12α-dihydroxy-derivative, and on choloyl-taurine.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37289-07-9


1. Nair, P.P., Gordon, M. and Reback, J. The enzymatic cleavage of the carbon-nitrogen bond in 3α,7α,12α-trihydroxy-5-β-cholan-24-oylglycine. J. Biol. Chem. 242 (1967) 7-11. [PMID: 6016335]

2. Stellwag, E.J. and Hylemon, P.B. Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis. Biochim. Biophys. Acta 452 (1976) 165-176. [PMID: 10993]

[EC created 1972]

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