IUBMB Enzyme Nomenclature


Accepted name: β-ureidopropionase

Reaction: 3-ureidopropanoate + H2O = β-alanine + CO2 + NH3

For diagram click here.

Glossary: 3-ureidopropanoate = N-carbamoyl-β-alanine

Other name(s): N-carbamoyl-β-alanine amidohydrolase

Systematic name: 3-ureidopropanoate amidohydrolase

Comments: The animal enzyme also acts on β-ureidoisobutyrate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9027-27-4


1. Campbell, L.L. Reductive degradation of pyrimidines. 5. Enzymatic conversion of N-carbamyl-β-alanine to β-alanine, carbon dioxide, and ammonia. J. Biol. Chem. 235 (1960) 2375-2378.

2. Caravaca, J. and Grisolia, S. Enzymatic decarbamylation of carbamyl β-alanine and carbamyl β-aminoisobutyric acid. J. Biol. Chem. 231 (1958) 357-365.

3. Traut, T.W. and Loechel, S. Pyrimidine catabolism: individual characterization of the three sequential enzymes with a new assay. Biochemistry 23 (1984) 2533-2539. [PMID: 6433973]

[EC created 1961]

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