IUBMB Enzyme Nomenclature

EC 3.5.1.66

Accepted name: 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase

Reaction: 2-(hydroxymethyl)-3-(acetamidomethylene)succinate + 2 H2O = acetate + 2-(hydroxymethyl)-4-oxobutanoate + NH3 + CO2

Other name(s): compound B hydrolase; α-hydroxymethyl-α'-(N-acetylaminomethylene)succinic acid hydrolase

Systematic name: 2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)

Comments: Involved in the degradation of pyridoxin by Pseudomonas and Arthrobacter.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, UM-BBD, CAS registry number: 95829-26-8

References:

1. Huynh, M.S. and Snell, E.E. Enzymes of vitamin B6 degradation. Purification and properties of two N-acetylamidohydrolases. J. Biol. Chem. 260 (1985) 2379-2383. [PMID: 3972793]

[EC 3.5.1.66 created 1989]


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