IUBMB Enzyme Nomenclature


Accepted name: maleimide hydrolase

Reaction: maleimide + H2O = maleamic acid

Other name(s): imidase; cyclic imide hydrolase; cyclic-imide amidohydrolase (decyclicizing) [misprint]; cyclic-imide amidohydrolase (decyclizing)

Systematic name: cyclic-imide amidohydrolase (ring-opening)

Comment: Succinimide and glutarimide, and sulfur-containing cyclic imides, such as rhodanine, can also act as substrates for the enzyme from Blastobacter sp. A17p-4. The reverse, cyclization, reaction is also catalysed, but much more slowly. It has lower activity towards cyclic ureides, which are the substrates of EC, dihydropyrimidinase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9030-74-4


1. Ogawa, J., Soong, C.L., Honda, M. and Shimizu, S. Imidase, a new dihydropyrimidinase-like enzyme involved in the metabolism of cyclic imides. Eur. J. Biochem. 243 (1997) 322-327. [PMID: 9030755]

[EC created 2001]

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