IUBMB Enzyme Nomenclature

EC 3.5.2.2

Accepted name: dihydropyrimidinase

Reaction: 5,6-dihydrouracil + H2O = 3-ureidopropanoate

Other name(s): hydantoinase; hydropyrimidine hydrase; hydantoin peptidase; pyrimidine hydrase; D-hydantoinase

Systematic name: 5,6-dihydropyrimidine amidohydrolase

Comments: Also acts on dihydrothymine and hydantoin.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9030-74-4

References:

1. Brooks, K.P., Jones, E.A., Kim, B.-D. and Sander, E.G. Bovine liver dihydropyrimidine amidohydrolase: purification, properties, and characterization as a zinc metalloenzyme. Arch. Biochem. Biophys. 226 (1983) 469-483. [PMID: 6639068]

2. Eadie, G.S., Bernheim, F. and Bernheim, J.L.C. Metabolism of cytosine, thymidine, uracil and barbituric acid by bacterial enzymes. J. Biol. Chem. 181 (1949) 449-458. [PMID: 15393763]

[EC 3.5.2.2 created 1961]


Return to EC 3.5.2 home page
Return to EC 3.5 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page