Reaction: S-methyl-5'-thioadenosine + H2O = 5'-S-methyl-5'-thioinosine + NH3
Other name(s): MTA deaminase; 5-methylthioadenosine deaminase
Systematic name: S-methyl-5'-thioadenosine amidohydrolase
Comments: The enzyme from Thermotoga maritima also functions as S-adenosylhomocysteine deaminase (EC 18.104.22.168) and has some activity against adenosine. Adenosine-5-monophosphate (AMP) and S-adenosyl-L-methionine (SAM) are not substrates.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Hermann, J.C., Marti-Arbona, R., Fedorov, A.A., Fedorov, E., Almo, S.C., Shoichet, B.K. and Raushel, F.M. Structure-based activity prediction for an enzyme of unknown function. Nature 448 (2007) 775-779. [PMID: 17603473]