IUBMB Enzyme Nomenclature


Accepted name: cytidine deaminase

Reaction: (1) cytidine + H2O = uridine + NH3
(2) 2'-deoxycytidine + H2O = 2'-deoxyuridine + NH3

Other name(s): cytosine nucleoside deaminase; (deoxy)cytidine deaminase; cdd (gene name); CDA (gene name)

Systematic name: cytidine/2'-deoxycytidine aminohydrolase

Comments: Contains zinc. Catalyses the deamination of cytidine and 2'-deoxycytidine with similar efficiencies. The enzyme, which is widely distributed among organisms, is involved in salvage of both exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9025-06-3


1. Roberts, D.W.A. The wheat leaf phosphatases. II. Pathway of hydrolysis of some nucleotides at pH 5.5. J. Biol. Chem. 222 (1956) 259-270. [PMID: 13366999]

2. Wang, T.P., Sable, H.Z. and Lampen, J.O. Enzymatic deamination of cytosine nucleosides. J. Biol. Chem. 184 (1950) 17-28. [PMID: 15421968]

3. Song, B.H. and Neuhard, J. Chromosomal location, cloning and nucleotide sequence of the Bacillus subtilis cdd gene encoding cytidine/deoxycytidine deaminase. Mol. Gen. Genet. 216 (1989) 462-468. [PMID: 2526291]

4. Laliberte, J. and Momparler, R.L. Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA. Cancer Res. 54 (1994) 5401-5407. [PMID: 7923172]

5. Vincenzetti, S., Cambi, A., Neuhard, J., Schnorr, K., Grelloni, M. and Vita, A. Cloning, expression, and purification of cytidine deaminase from Arabidopsis thaliana. Protein Expr. Purif. 15 (1999) 8-15. [PMID: 10024464]

[EC created 1961, modified 2013]

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