IUBMB Enzyme Nomenclature

EC 3.5.99.4

Accepted name: N-isopropylammelide isopropylaminohydrolase

Reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine

Glossary: cyanuric acid = 1,3,5-triazine-2,4,6(1H,3H,5H)-trione = 2,4,6-trihydroxy-s-triazine

Other name(s): AtzC

Systematic name: N-isopropylammelide isopropylaminohydrolase

Comments: Involved in a pathway by which the herbicide atrazine, 2-chloro-4-(ethylamino)-6-(isopopylamino)-1,3,5-triazine, is degraded in bacteria via N-isopropylammelide, 2,4-dihydroxy-6-(isopropylamino)-1,3,5-triazine.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, UM-BBD, CAS registry number: 203810-02-0

References:

1. Sadowsky, M.J., Tong, Z., de Souza, M. and Wackett, L.P. AtzC is a new member of the amidohydrolase protein superfamily and is homologous to other atrazine-metabolizing enzymes. J. Bacteriol. 180 (1998) 152-158. [PMID: 9422605]

[EC 3.5.99.4 created 2000]


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